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Sitting

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In 1700, De Morbis Artificum Diatriba, listed sitting in odd postures as a cause of diseases in “chair-workers”. Current studies indicate there is a significantly higher mortality rate among people who regularly sit for prolonged periods, and the risk is not negated by regular exercise, though it is lowered. The causes of mortality and morbidity include heart disease, obesity, type 2 diabetes and cancer, specifically, breast, endometrial, colorectal, lung, and epithelial ovarian cancer. The link between heart disease and diabetes mortality and sitting is well-established, but the risk of cancer mortality is unclear. Sedentary time is also associated with an increased risk of depression in children and adolescents. A correlation between occupational sitting specifically and higher body mass index has been demonstrated, but causality has not yet been established. There are several hypotheses explaining why sitting is a health risk. These include changes in cardiac output, vitamin D, inflammation, sex hormone activity, lipoprotein lipase activity, and GLUT4 activity due to long periods of muscular unloading, among others.

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